One potential avenue of treatment for TBI is infrared light, which has shown promising data in a number of applications. Near-infrared (NIR) light has been investigated for its ability to modulate intracellular mechanisms related to healing. The application of NIR light by low-power laser or by light-emitting diode (LED) is also known as laser phototherapy or near-infrared photobiomodulation. NIR irradiation can facilitate wound healing, promote muscle repair, and stimulate angiogenesis. NIR phototherapy has been studied and applied clinically in a wide array of ailments, including skin ulcers, osteoarthritis, peripheral nerve injury, low back pain, myocardial infarction, stem cell induction and traumatic brain injury.